SARMS, a.k.a Selective Androgen Receptor Modulators, Does it ring any bells? Its commonly referred as an alternative to steroids which benefits include being the more efficient at cycling steroids and at post cycle therapy (PCT). This is our topic of discussion today and I will give you the basics (And some points that are not all that basic) about SARMs so you can begin to understand everything you need to know about them.
SARMs are a group of compounds intended to have steroid like action but with a more narrow focus, However, even if they can be nonsteroidal variants, steroidal variants also exist.
Some History and Background of SARMs
Since its most early introduction to mainstream science and clinical testing in the early 90s, SARMs have been controversial, this is not to say that SARMs have been here since the 90s, rather steroidal SARMs have been used medically for bone and muscle wasting illnesses as early as the 1940s, when were used as a treatment for Hypogonadism, osteoporosis, some types of cancer and many other afflictions. These steroidal SARMs had a very high affinity, thus having a significant impact in muscle building. In common words, steroidal SARMs’ attraction to steroid receptors is high and this makes chemical reactions in the body more powerful.
Unlucky, steroidal SARMs were not a perfect solution, since they came with side effects such as estrogen conversion which causes gynecomastia (puffy and sensitive nipples in men), damage to liver and kidneys (related to its particular methylation) and decreased libido. Another side effect was that steroids can change the DNA of particular cells in the prostate and heart for example, causing them to grow larger and larger.
Steroidal VS Non Steroidal SARMs
The first nonsteroidal versions of these SARMs were created in the 1990s. The main difference is that these new SARMs were based on proteins. The basic differences of both steroidal and nonsteroidal SARMs can be pictured as a lock and key system, where the cells in the body act as locks and the binding sites (receptors) as key holes. Steroidal SARMs can function then as a master key by binding with any cell to promote protein synthesis and growth, even with cells you would rather not “unlock”.
Nonsteroidal SARMs are specifically designed as to only bind with certain locks (think it as the difference between a master key and a particular key) as to only affect certain cells in order to activate only parts of the DNA which prevent muscle and bone wastage while promoting the growth of said areas.
This newer type of SARMs (nonsteroidal) have since been used for bodybuilding, powerlifting and a plethora of other sports since its rise to popularity/ Their benefit to side effect ratio has been tested since the 1990s and no clear evidence of harm has ever been observed. This breakthrough scientific technology keeps suggesting SARMs to be the future of anabolics and to one day completely replace steroid therapy.
However, this is not a “SARMs are the go to answer for all problems” argument either. although protein based SARMs have a limited side effects list and a large list of benefits for strength and muscle growth, they also require a longer use period and cannot compare yet to the results of steroids. The unwanted side effects versus benefit ratio has been studied for decades.
SARMs, compared with testosterone cypionate are over 200 times more powerful in muscle stimulation and 80 times more selective when it comes to which muscle cells trigger and which not to.
Here's a video explaining it:[embed]https://www.youtube.com/watch?v=RgA3wzTlh4I[/embed]
SARMs’ benefits vs. Prohormones’ benefits
Prohormones were the first option in the market. Regardless of them being the first introduced to the market, synthetic steroids or testosterone supplements don’t have the same muscle growth effects of authentic steroids and with the drawback of carrying the same adverse side effects, making them unfit for human use.
Despite all of the above, SARMs are an upgrade over classic anabolic steroids. It can be administered orally, minimizing the effects of high testosterone in blood levels. SARMs are also believed to cure various diseases which steroids and other medicines treated before. It also shows promising results in replacing androgen which can yield a comparable desirable result on muscle tissue as steroids.
According to research conducted by the Word anti-doping Agency or WADA, approximately 1 in 10 athletes around the globe uses SARMs, specially Ostarine, to enhance their performace, this being considered a safe performance boost.
Some studies have even show SARMs ability to increase muscle and bone mass dramatically in animals while having no notable adverse impact on the prostate. Phase 1 trials of SARMs in humans have also reported significant increases in lean muscle mass. the two most common SARMs among bodybuilders are SARM S-4, chemical name Acetamidoxolutamide and SARM S-1 or commonly known as Ostarine or MK 2866
How Do They Work?
As we grow older, our endurance, power and skeletal muscles’ mass deteriorates due to the loss of type 2 myofibrils (muscle cells). This hinders the normal function of the muscle and thus it impedes the normal functioning of the individual. with SARMs, skeletal muscle mass and strength in people with androgen deficiency can be enhanced.
There are 2 ways to administer SARMs, orally or with injectable dosages. The anabolic effect can be expected to be comparable to testosterone. In addition, it is said to produce improvements in bone mineral deficiency depending on the dosage and an increase in motor strength, this even without considering its power to reduce body fat and increase lean body mass.
SARMs link to the same receptor as classic steroids would, as Dianabol and Testosterone, but this non steroidal SARMs wont also bring about the side effects of traditional steroids and prohormones. This fresh start in the advancements in muscle pharmacology can then offer the enhancement of muscle mass, while reducing body mass and boosting your athletic performance beyond the previous limits.
- SARMs is believed to be able to employ the same effects and benefits of anabolic supplements, yet reducing the side effects of steroids.
- It’s non-toxic, so it won’t damage your liver
- It can avoid bone loss (direct action of testosterone in bone through the AR-mediated conduit is critic from its anabolic effects in bone)
- Doesn’t pose the huge prostate cancer risk, without jeopardizing muscle mass gain
- Won’t impede your HPTA
- Comparable effects to testosterone
- No estrogen and Dihydrotestosterone (Hydrogen hormone) conversion
- It’s virtually untraceable
Last but not Least:
For muscle builders:
- Muscle loss prevention (during cutting period)
- Development in lean muscle
- Improvement in strength
- A cut down injury recovery times
- Join healing abilities
- Anabolic use followed by PCT
Side Effects of SARMS
The great thing about SARMs is that its side effects are negligible, so you dont have much to worry about
Most Popular SARMS
There are many SARMs, but here I will list 4 of the main SARMs currently offered in the market and the most applicable to athletes, bodybuilders and fitness enthusiasts:
LGD-4033 - Nonsteroidal, mainly for bodybuilding, mainly enhances lean muscle mass and reduces body fat.
Ostarine (MK-2866) - Selective for anabolic activity at specific ARs. Best for maintaining and increasing lean body mass and recomping.
S4 (Andarine) - mainly for bone tissue (mostly low virilization), aimed to cure osteoporosis and won’t produce development of prostate and other secondary sexual organs.
GW 501516 (Cardanine)* - Burns fat, prevents muscle loss and helps you take your training to the next level. Commonly referred to as “the king of endurance supplements” and is used by some top bodybuilders and athletes.
*GW 501516 is a PPAR agonist and therefore NOT A SARM. However it’s grouped among them in the bodybuilding community and thus included here.
Where to Buy SARMs Online
Many manufacturers are selling SARMs right now.
Everyone who has tried SARMs has without a doubt heard of them. You can visit them Here
With SARMs are showing great potential for selective high anabolic muscle activity while preventing muscle wastage and age related afflictions, all without compromising with large lists of negative side effects associated with anabolic steroids and prohormones. SARMs could potentially be the next big thing in this area.
The International Olympic Committee (IOC) is even preparing for the use of SARMs among Olympic athletes. It’s “Anabolics on steroids” or if you prefer, “Anabolics 3.0” and the Universal “Soldier Formula” of the future!
What are your thoughts on Anabolics and more specifically SARMs? Please, feel free to leave your comments, suggestions and ideas below.
Benefits Dosages & Protocols References
Increased muscle Strength: Asian Journal of Andrology: Subjects increases muscle strength 20 fold more than those in the placebo group. Subjects continued this gain in strength and muscle size for up to 5 months but with lower percentage of effectiveness right around the third month (Dalton et al, 2014).
Increased muscle size: Deductive evidence was used to prove a significant increment in tissue hypertrophy (muscle mass growth). Inductive evidence has also suggested that subjects will gain between 3 and 15 lbs of muscle tissue over 12 weeks of use (Dubois et al, 2015). The amount of muscle hypertrophy depends on diet, training, and the characteristics of the SARM implemented. Mild SARMs such as MK 2866 will produce much lower hypertrophy than more potent SARMs such as RAD 140 or LGD 4033.
Tissue selectivity: According to the Oxford Academic Journal of Endocrinology, nonsteroidal SARMs have have been designed to attach themselves to receptors to trigger specific DNA sequences responsible for skeletal muscle protein synthesis. Unlike other anabolic agents, nonsteroidal SARMs do no effect over any other tissues in the body (Dubois et al, 2015).
Inhibits cancer cell division: In a non related muscle growth research performed at the Public Library of Science’s (PLOS) Peer Reviewed Open Access Journal, nonsteroidal SARMs have been researched for its effects on breast cancer. Androgen receptors are known to play a key role in the treatment of breast cancer, and due to the inability for nonsteroidal SARMs to convert to estrogen, there is a very narrow probability for negative outcomes. The results of the study not only confirmed that tumor cells decrease in weight by 90%, however it might be possible that it even inhibits the potential for breast cancer development, but this is unconfirmed (Dalton et al, 2014).
Regulation of libido: Recent studies have shown healthy increases in sexual desire in both men and women with the use of nonsteroidal SARMs. Males with hypogonadism, testosterone therapy is a common occurrence. In the latter, there are many undesirable effects that can and often will result in severe consequences for the user, such as blood thickening which commonly causes strokes and heart attacks, prostate enlargement and posterior development of prostate cancer, and gynecomastia, characterized as the development of female like breasts on men due to an overproduction of estrogen. An article published in 2014 by the Asian Journal of Andrology stated that “SARMs’ beneficial pharmacology and desirable pharmacokinetics offer considerable promise in the treatment of late onset hypogonadism. The convenience of once daily oral therapy combined with defined safety margins surrounding a proven efficacious dosage form may one day challenge testosterone replacement therapy as the gold standard in treating late onset hypogonadism” (Dalton et al, 2014).
In the Journal of Pharmacology and Experimental Therapeutics, researchers reported positive effects of nonsteroidal SARMs on females with decreased secual motivation, thus indicating a noticeable increase in secual desire (Jones et al, 2010)
Safety and tolerability: The Oxford Journal of Gerontology, Series A: Biological Sciences and Medical Sciences, stated that popular nonsteroidal SARM LGD 4033 (a.k.a. Ligandrol) has been recently studied for its effectiveness and safety in young, healthy males. Results favorably showed that hormone and lipid levels returned to normal without the use of a PCT (Post Cycle Therapy). No danger was detected through the study, although there were some noticeable adverse reactions. Because LGD 4033 is considered to be one of the strongest and most potent nonsteroidal SARMs on the market, it’s unlikely, although not entirely impossible that less potent SARMs will eventually produce some harmful effects (Bhasin, 2010)).